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The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
′-dithiobisindoles is described. In addition, the heterocyclic core of the marine alkaloid echinosulfone A, namely 3,3′-bis(indolyl) sulfone, was obtained by treatment of a 3-lithioindole derivative with bis(phenylsulfonyl) sulfide. These methodologies offer...
Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1
(2009-03-27)
and with histones, and that the p300-MAML1 complex specifically acetylates the tails of histones H3 and H4. Furthermore, we showed that MAML1 is acetylated by p300, and identified conserved lysines in the MAML1 N-terminus as the target for p300 acetylation. We found...
Studies of histone modification systems in Schizosaccharomyces pombe
(2010-05-26)
150D the reverse transcripts decreased to 25% of wild type levels. In the double mutant dcr1delta/rpb7-G150D the reverse transcript levels remained low indicating that Rpb7 functions upstream of Dcr1 in the RNAi pathway that maintains the H3K9me2...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
3 times higher compared to C-section indicating fetal peptide release. Neutrophils from cord blood after normal delivery contain 10 times more cytoplasmatic cathelicidin peptide compared to corresponding cells after C-section where a strict granular...
Intramuscular or periosteal acupuncture for patients with chronic musculoskeletal pain in the neck and low back : effects on pain, physical and psychological functioning
(2008-10-23)
Background: Periosteal acupuncture has shown promising results in the
clinic. No studies of effects in patients with chronic pain in the neck
and low back are today available.
Aims: The main purpose was to compare ...
Cancer vaccine strategies and studies of human thioredoxin reductase splice variants
(2010-05-28)
genomic structure, leading to numerous splice variants. Peculiarly, the v3 splice variant encompasses a unique glutaredoxin domain, transcription of which is guided by an alternative promoter, which is located upstream of the TrxR1 core promoter...
Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease
(2008-05-14)
Dopamine is fundamental in human behavior for movement, cognition and
reward. A dysfunctional dopamine system is implicated in several
neurological and psychiatric disorders such as Parkinson s disease and
schizophrenia. ...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...
New apheresis techniques in transplantation
(2008-11-21)
compatible living donor kidney recipients. Mean follow-up was 3 years and the study showed that clinical outcome is similar after ABO incompatible kidney transplantation with this protocol compared with ABO compatible kidney transplantation, both short...