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Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Muscle mass and function after total hip arthroplasty
(2009-04-17)
muscles recovered fully. There was still a reduction in CSA for m. iliopsoas (7.0 %) and hip adductors (8.4 %) and in RD for mm. gluteus maximus (10.1 HU), gluteus medius/minimus (5.6 HU), iliopsoas (3.9 HU) and adductors (2.4 HU). Limp was recovered...
Structural enzymology of dormancy related proteins from Mycobacterium tuberculosis
(2009-01-09)
mycobacteria and that tuberculosis accounts for approximately 2 million deaths annually. Treatment of this disease is complicated by the ability of Mycobacterium tuberculosis to switch from the active form into a persistent phase. In this phase the bacteria...
Tissue biomarkers in prostate cancer
(2009-09-25)
Prostate cancer (PC) is the most common male cancer in the western world. Better biomarkers are needed to support diagnosis, prediction of prognosis and treatment decision Radical prostatectomy (RP) specimens are routinely ...
Factors associated with lung function impairment in children and adults with obstructive lung disease
(2008-05-14)
Obstructive lung diseases are a group of diseases in which there is a limitation in the flow of air into or out of the lungs. Two common such diseases are asthma, which is found in both children and adults, and chronic ...
Gut microflora associated characteristics in children with celiac disease
(2009-05-08)
Aim: The over-arching aim of this thesis was to study some metabolic functions of the gut microflora in children with known or screening detected celiac disease (CD) and their first-degree relatives.
Materials: Study ...
The risk of malignancy in women with endometriosis
(2010-03-05)
with endometriosis and ovarian cancer (cases) and 416 controls were scrutinized (paper IV). The study showed strong reductions in risk for ovarian cancer after one-sided oophorectomy in both the univariate and multivariate analyses (OR 0.42 and OR 0.19, respectively...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
-phenylbutyrate (4-PB) and the demethylation agent, 5-Aza-2’deoxycytidine (5-Aza-dC) had minor effects on medulloblastoma cell cytotoxity when used as single agents. A significant enhancement in cell cytotoxity was seen when these drugs were combined with imatinib...
Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery
(2009-05-08)
-860) in the aprotinin group vs. 1210 mL (95%CI:860-1550) in the control group (p=0.004). The aprotinin group received fewer transfusions of packed red blood cells (0.9 U, 95%CI:0.1-1.7, vs. 2.7 U, 95% CI:1.4-4.1; p=0.01), platelets (0.1 U, 95%CI:0-0.3, vs. 0.6 U, 0.2- 0...
Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism
(2009-11-06)
Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1...