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Molecular genetics of cutaneous malignant melanoma
(2007-08-24)
Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the
skin with rapidly increasing incidence. Patients with advanced disease
have a poor prognosis since the tumor is usually resistant to current
therapies. ...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Caesarean section on maternal request : personality, fear of childbirth and signs of depression among first-time mothers
(2007-05-15)
Aim: The overall aim of this thesis was to study healthy first-time mothers
requesting and undergoing an elective caesarean section (CS) and to
compare these to healthy first-time mothers planning a vaginal delivery.
The ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Epidemiological aspects on pain in whiplash-associated disorders
(2007-03-23)
Introduction: Whiplash-associated disorders (WAD) are common after car collisions. Little is known about risk factors for onset of the injury or about factors influencing the recovery.
Objective: The general objective ...
Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta : effects on clinical symptoms and bone turnover
(2007-10-25)
compression fractures. In Study III eleven infants aged 3-13 months were treated during 3-6 years and were at the latest recording at median age of 4.8 years compared to our own historic control group of untreated age and type-matched children with OI...
The impact of airway-irritating exposure and wet work on subjects with allergy or other sensitivity : epidemiology and mechanisms
(2007-09-14)
The prevalence of asthma and allergies is increasing, which means that
the proportion of workers on the labour market with allergy or other
sensitivity also increases. It is as of yet not known to what extent
these ...
Role of estrogen receptor beta in mouse prostate and bladder with references to human diseases
(2007-11-15)
After the discovery of estrogen receptor beta (ERbeta) in 1995, it
became clear that in many non-classical estrogen-responsive organs,
were in fact direct targets for estrogen. One of these organs is prostate
gland, ...