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Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Studies of ischemia and reperfusion in muscle and liver on glutathione and amino acid metabolism in man
(2007-11-23)
ischemia, at maximal ischemia and after 10 min, 4, 24 and 48 hours
of reperfusion. In a second study aorto bi-femoral surgery patients were
studied because of the longer ischemia times up to 120 minutes with this
procedure. Biopsies from both legs were...
Functional genomics studies of PINK1
(2007-10-25)
uptake. Secondly, FABP4, a lipid transport protein, was selectively down regulated following PINK1 knockdown in adipocytes. However, mitochondrial genes were not altered when PINK1 expression was ablated, despite the in vivo association between such genes...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
tissue. Activation of B lymphocytes is accompanied by alternations in chemokine responsiveness that brings together the antigen specific B cells with its cognate CD4 T cell. Several human viral infections have been shown to interfere with chemokine...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...
Strategies to improve macroencapsulated islet graft survival
(2007-10-05)
the effects of exendin-4 treatment on
the metabolic outcome after islet transplantation. Exendin-4 inhibits
islet apoptosis, stimulates islet differentiation and regeneration and
has beneficial effects on peripheral tissues. We found that exendin-4
treatment...