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Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
participating in a support- and
education programme had significantly more knowledge about stroke after
12 months compared to the controls. No difference in psychological health
was found. However, the 5 participants appreciated the group sessions...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Analysis of neuropathic pain after spinal cord injury
(2008-01-18)
Longstanding neuropathic pain is a challenge in spinal cord injury (SCI) rehabilitation. Once established it is difficult to treat successfully. Neuropathic pain has a negative influence on quality of life and on the outcome ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
Environmental factors are likely contributing factors in the development of Rheumatoid Arthritis (RA), an autoimmune disease, for which etiologic factors are still poorly known. Mineral oils are efficient adjuvants which ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Molecular mechanisms of estrogen action in relation to metabolic disease
(2007-11-16)
Estrogens have multiple effects on the body. Most studied are the
effects on female reproduction. In this thesis, we have focused on the
metabolic effects of estrogens. Estrogen treatment decreases adipose
tissue mass ...
Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria
(2007-02-09)
Artemisinin (ART) class of compounds are of special interest due to their
rapid onset of action and high activity against multidrug resistant
malaria. The major drawback in monotherapy with ART and its derivatives
is ...
Analysis of kidney glomerular and microvascular transcriptomes
(2007-09-21)
Kidney glomeruli play a crucial role in the maintenance of body homeostasis. Many diseases attack the kidney function by primarily affecting glomeruli. However, the transcriptome profiles and the function of the glomerulus ...