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Gene regulation and immune mechanisms in multiple sclerosis experimental models
(2007-09-04)
) and 10th (G10) generation of an advanced intercross line between susceptible DA and resistant, but MHC identical, PVG.AV1 strains confirmed their influence on MOG-EAE. Very narrow QTL confidence intervals with restricted sets of genes were demonstrated...
Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells
(2006-12-29)
Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of ...
Cardiovascular disease among professional drivers and subway staff in Stockholm
(2007-03-30)
,482 controls to investigate possible causes of the increased risk of MI in professional drivers, and to study the risk in bus, taxi and truck drivers (Paper 1). The second is a register-based case-control study of first MI cases recruited in Stockholm County...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies
(2007-11-23)
Background: Rheumatoid arthritis (RA) is a common autoimmune disease
characterized by chronic polyarticular synovial inflammation. Erosive
joint destruction represents a major unsolved complication of RA.
Objectives: ...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
for the highest versus the lowest quartile of the apoB/apoA-1 ratio was 2.88 (2.54 to 3.26) compared to HR, 3.35 (2.25 to 4.91) for those with CKD. After adjustment for the total cholesterol/ high-density lipoprotein cholesterol ratio, an increase by one standard...
Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock
(2007-05-18)
and endothelin-1 levels was elicited. HSD resuscitation transiently improved cardiac index and mean arterial pressure. Regional blood flow increased in the renal and carotid, but not portal circulation. The progression of acidosis was delayed and the macro...
Metabolic roles of adenosine : studies using genetically modified mice and transfected cells
(2007-11-23)
The aim of this thesis was to further investigate the metabolic roles of
adenosine. The endogenous nucleoside adenosine acts by binding to the
four adenosine receptors, A1R, A2AR, A2BR and A3R. The A1R is the
adenosine ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Truncation and missing family links in population-based registers
(2008-03-07)
Studies of familial aggregation of disease routinely use linked
population registers to construct retrospective cohorts. Although such
resources have provided numerous estimates of familial risk, little is
known regarding ...