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Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
About 30,000 people in Sweden are affected by stroke each year. The
effect on physical functioning, and also consequences such as depression
and aphasia, are likely to affect not only the life of the patient, but
also the ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies
(2007-11-23)
Background: Rheumatoid arthritis (RA) is a common autoimmune disease
characterized by chronic polyarticular synovial inflammation. Erosive
joint destruction represents a major unsolved complication of RA.
Objectives: ...
Differences i tropism and viral assembly pathways of human herpesvirus 6A and 6B (HHV-6A and 6B) and association of host cell proteins in HHV-6A virions
(2007-05-24)
Human herpesvirus 6A and 6B (HHV-6A and 6B) are considered to be T-lymphotropic viruses. The overall nucleotide sequence identity between the two variants is 90% and each differs by only nine variant-specific open reading frames. HHV-6A and 6B have...
B-cell survival factors in multiple sclerosis and myasthenia gravis
(2007-03-14)
Multiple sclerosis (MS) is a chronic, progressive neurological disease in which death of myelin-producing oligodendrocytes and axonal damage are prominent pathological features. The cause of MS is unknown but genetic and ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta : effects on clinical symptoms and bone turnover
(2007-10-25)
protocol every six month for 1-2 years then annually. In Study I three adolescents with severe OI were treated during 2-5 years. In Study II we treated 28 children aged 0.6-18 years during 2-9 years. They had severe or milder forms of OI with vertebral...