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Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
by immature rats Leydig cells., (ii) possible antiapoptotic effects of IGF-I during testicular development and the role played by IGF-1R in this context; (iii) the influence of IGFBP-3 on apoptosis and steroidogenesis in rat Leydig cells in relation...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
for the highest versus the lowest quartile of the apoB/apoA-1 ratio was 2.88 (2.54 to 3.26) compared to HR, 3.35 (2.25 to 4.91) for those with CKD. After adjustment for the total cholesterol/ high-density lipoprotein cholesterol ratio, an increase by one standard...
Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies
(2007-11-23)
Background: Rheumatoid arthritis (RA) is a common autoimmune disease
characterized by chronic polyarticular synovial inflammation. Erosive
joint destruction represents a major unsolved complication of RA.
Objectives: ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications
(2007-08-17)
Uveal melanoma is the most common primary intraocular malignant tumor in
adults with 30% to 50% of patients that ultimately succumb to metastatic
disease, mainly to the liver. Although new diagnostic and therapeutic
tools ...
Mother and newborn adaptations after birth : influence of administration of oxytocin and epidural analgesia during labour
(2009-08-31)
: 1) mothers who had received intravenous oxytocin during labour (OT iv group, n=10), 2) mothers who had received oxytocin intramuscularly after birth to prevent postpartum haemorrhage but no other treatment (OT im group, n=15) and 3) mothers who had...
Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion
(2007-05-25)
Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or ...
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
to become ex-posed to ethanol following ingestion. In this thesis I explored their reactions to ethanol and EtP in the setting of an acute inflammatory reaction, e.g. after challenge with LPS, IL-1, TNFalpha or LTB4 mimicking, for instance, sepsis...
Charcterization of biotransformation systems in human cells
(2007-05-25)
and xenobiotic-induced hepatotoxicity, the expression of biotransformation enzymes was evaluated. The protein expression of glutathione transferases (GSTs) in hepatocyte-like cells was studied and results show high levels of GSTA1-1, whereas GSTP1-1...