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β-alanine synthase : one reaction, two folds and mechanisms
(2008-01-11)
beta-alanine synthase (betaAS) is the third enzyme in the reductive
pyrimidine catabolic pathway which is responsible for the breakdown of
pyrimidine bases, including several anti-cancer drugs in higher
organisms. We ...
Identification of susceptibility genes in type 2 diabetes
(2008-01-04)
Identification of the susceptibility genes will offer better
understanding of molecular mechanisms underlying T2D pathogenesis, and
subsequently may lead to development of novel therapeutic approaches.
This thesis mainly ...
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas
(2007-11-07)
machine with high throughput capabilities which integrates with other commercial high content screening systems. These technologies were successfully applied to measure [Ca2+]i and hormone release from batches of damaged islets with decreased viability...
Functional genomics studies of PINK1
(2007-10-25)
known risk factor for type 2 diabetes. Gene expression profiling of skeletal muscle from subjects before and after 5 weeks of inactivity by quantitative real-time PCR demonstrated a co-ordinated reduction in mitochondrial gene expression. We thus...
Role of inflammatory and mitochondria genes in adipose tissue and obesity
(2007-09-28)
Obesity is rapidly increasing in prevalence around the world together with its complications such as dyslipidemia, cardiovascular disease (CVD) and insulin resistance, which eventually may lead to type 2 diabetes (T2DM). The excess of adipose tissue...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...
Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo
(2008-01-24)
The cytochrome P450 (P450) enzymes comprise the most important enzyme
system with regard to phase I metabolism of drugs. Induction of P450s can
result in decreased plasma concentrations of the drug itself or a
coadminstered ...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...