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Weight loss programmes over the internet : opportunities and limitations
(2007-11-21)
was automatically monitored and
downloaded to a database.
Results: Eighty-six percent of the members were female, and the age range
was wide (range 18-101y; mean 40.3 ± 11.5y). At baseline, BMI of the
entire group was 29.3 ± 5.1 kg/m2 with 39% obese and 45...
Passive volume reduction heart surgery using the Acorn CorCap cardiac support device
(2007-09-14)
Heart failure is a growing health problem, affecting an increasing number
of patients with rapidly increasing costs for the health care system. In
spite of recent improvements in pharmacological, non-pharmacological ...
Method specific factors in personality tests
(2007-09-21)
Two of the most widely used personality assessment methods are the
Rorschach (Exner, 1993) and the MMPI/MMPI-2 (Hathaway & McKinley, 1943;
1989). Both methods have demonstrated validity for particular purposes
(Meyer & ...
Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5
(2007-11-27)
involvement was not
detected.
In paper IV, alternative Cdk5 substrates were looked for in Cdk5/p25
transfected HEK293 cells. A non-muscle myosin heavy chain, type B
(NMHC-B), was identified as a novel Cdk5 substrate. Only Cdk5
phosphorylates NMHC-B in HEK293...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Ion channels in drug discovery : focus on biological assays
(2008-04-04)
Ion channels are well characterised drug targets. However, the techniques
used to study ion channel pharmacology have not been particularly
applicable to modern drug discovery. The aim of this thesis was to
examine the ...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas
(2007-11-07)
Human islet transplantation is emerging as an alternative to pancreas transplantation or insulin therapy in the treatment of type I diabetes. It has been possible to achieve euglycemia by transplanting isolated human islets ...
Misoprostol : pharmacokinetics and effects on uterine contractility and cervical ripening in early pregnancy
(2007-08-17)
Misoprostol is an orally active synthetic PGE1 analogue which has become
an important drug in obstetric and gynaecological practice because of its
uterotonic and cervical priming actions. It is safe, cheap, widely
available ...