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Perceived allergy and hypersensitivity – especially food hypersensitivity – and the consequences for children, adolescents and their families
(2007-10-26)
Background: Allergy and hypersensitivity are growing health issues with impact on the individual’s physical and psychosocial quality of life, work and social life. This thesis focuses on children and adolescents with ...
Method specific factors in personality tests
(2007-09-21)
Two of the most widely used personality assessment methods are the
Rorschach (Exner, 1993) and the MMPI/MMPI-2 (Hathaway & McKinley, 1943;
1989). Both methods have demonstrated validity for particular purposes
(Meyer & ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Identification of the susceptibility genes in type 1 diabetes and diabetic nephropathy
(2007-11-02)
Genetic susceptibility plays an important role in the pathogenesis of
type 1 diabetes (T1D) and diabetic nephropathy (DN). The present study
aims to investigate the association between single nucleotide
polymorphisms ...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
by immature rats Leydig cells., (ii) possible antiapoptotic effects of IGF-I during testicular development and the role played by IGF-1R in this context; (iii) the influence of IGFBP-3 on apoptosis and steroidogenesis in rat Leydig cells in relation...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
-modulated factor 1 (PMF-1) and germinal center associated
nuclear protein (GANP) in glucocorticoid signalling.
RIP140 represses ligand activated nuclear receptors, such as GR and LXR.
It is localized in small nuclear foci targeted by a 40 amino acid long
sequence...
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(2007-01-05)
induces signals via MEKK1, however, the activation of calpain is shown to be independent of overexpression of the dominante negative form of MEKK1 (dnMEKK1). The dominant positive form of MEKK1 (Dp MEKK1) induces a conformational change in the proapoptotic...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...