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Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs
(2007-04-13)
Anticancer drug treatment gives rise to complex cellular responses in
tumor cells. An improved understanding of the mechanisms underlying these
responses is important in order to improve treatment. It is also of
importance ...
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(2007-01-05)
, the effects of sensitizing tumor cells to cisplatin by inhibition of their energy production are investigated. Both an inhibitor of glycolysis, 2-deoxyglucose (DG) as well as an inhibitor of fatty acid â oxidation, etomoxir, were shown to potentiate...
Role of inflammatory and mitochondria genes in adipose tissue and obesity
(2007-09-28)
Obesity is rapidly increasing in prevalence around the world together with its complications such as dyslipidemia, cardiovascular disease (CVD) and insulin resistance, which eventually may lead to type 2 diabetes (T2DM). The excess of adipose tissue...
Analysis of kidney glomerular and microvascular transcriptomes
(2007-09-21)
Kidney glomeruli play a crucial role in the maintenance of body homeostasis. Many diseases attack the kidney function by primarily affecting glomeruli. However, the transcriptome profiles and the function of the glomerulus ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Risk indicators for esophageal cancer : some medical conditions and tobacco-related indicators
(2007-05-14)
Because of little progress in the prognosis and survival of esophageal
cancer patients, the early diagnosis and prevention have been
prioritized. Alcohol consumption and tobacco smoking are the main risk
factors of ...
Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects
(2008-04-04)
Oxaliplatin is a platinum-based cytostatic drug. It is used in
combination with 5-fluorouracil and leucovorin for palliative and
adjuvant treatment of metastatic colorectal cancer. The biotransformation
of oxaliplatin ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...