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Genome wide analysis of the Ssn6-Tup11/Tup12 co-repressor complex in the fission yeast Schizosaccharomyces pombe
(2007-02-15)
HDAC. A subset of co-repressor target genes,
including direct target genes affected by Ssn6 overexpression, is in
addition associated with the function of class II (Clr3) and III (Hst4
and Sir2) HDACs. Interestingly, many specific Hst4 repressed ORF...
Molecular epidemiology of pneumococcal carriage and invasive disease
(2007-02-02)
of antibiotics decreased. However, the prevalence of multi
resistant isolates increased. Among PNSP, serotype 14 increased due to
one clonal cluster, the internationally spread clone Spain9v-3 with STI
56. One reason for the successful spread was suggested...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
out at pH 5.7. The pathway of this base flipping is studied. We demonstrate that the minor groove pathway is preferred over the major groove pathway, and that protonation on an A adjacent to the flipping U lowers the energy barrier ~3.5 kcal...
Genetically determined interindividual variation in cytochrome P450 dependent drug metabolism : molecular basis and clinical implications
(2007-02-02)
Pharmacogenetics is the study of genetic variation that causes variation
in drug levels (pharmacokinetics), drug response (pharmacodynamics) and
adverse drug reactions. Pharmacogenetics aims at identifying biomarkers
that ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Histone deacetylases and their co-regulators in Schizosaccharomyces pombe
(2007-03-02)
chromosome segregation defects and derepression
of centromeric silencing.
Rpd3 in S. cerevisiae is recruited to genomic targets by interacting with
co-regulator Sin3. S. pombe has three Sin3 homologs. Pst1 interacts with
the HDAC Clr6, and like Clr6...
The N-methyl-D-aspartate receptor subunit NR3A : cloning, expression and interacting proteins
(2008-03-28)
This thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least one NR1, probably two NR2...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
binding motifs in the hTERT promoter and is required for maintenance of histone H3-K4 trimethylation in this region. Knocking down SMYD3 in some tumor cell lines abolished trimethylation of H3-K4, attenuated the occupancy by the transactivators c...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...