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The illness flexibility model and sickness absence
(2007-05-11)
Research on sickness absence has repeatedly been described as
theoretically undeveloped. In this thesis the model of illness
flexibility is introduced. In this model, sickness absence is assumed to
be caused by people’s ...
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
.0-1.7). Mineral oil exposure was associated with a particularly high risk of developing rheumatoid factor positive RA (RR =1.4, 95% CI =1.0-2.0) and anti-citrulline positive RA (anti-CCP+RA) (RR =1.6, 95% CI=1.1-2.2). The highest risk of developing anti- CCP...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
the levels of the expression of phosphorylated IGF receptor type 1 (p-IGF1R), caspase-3, Bcl-2, and IGFBP-3 in Leydig cells at different stages of development. The IGF receptor type 1(IGF1R) are expressed primarily in the adult testis and IGF-I participates...
Transcriptional regulation by inner nuclear membrane proteins
(2007-04-19)
, bind promoters of SPS-sensor regulated genes and induce their transcription. Recessive loss-of-function mutations in ASI1, ASI2 and ASI3 (amino acid sensor independent) genes bypass the requirement of a functional SPS-sensor and constitutively induce...
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Nephrin : intracellular trafficking and podocyte maturation
(2007-11-23)
Congenital nephrotic syndrome of the Finnish type, CNF, is an autossomal
recessive disorder caused by mutations in the NPHS1 gene and,
consequently, in its product nephrin, a 180 kDa transmembrane protein
belonging to ...
Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas
(2007-11-07)
machine with high throughput capabilities which integrates with other commercial high content screening systems. These technologies were successfully applied to measure [Ca2+]i and hormone release from batches of damaged islets with decreased viability...