Search
Now showing items 1-10 of 285
Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat
(2007-05-25)
The aim of the thesis was to investigate the effects of the 5-HT1A
receptor antagonist robalzotan (NAD-299) and the 5-HT1B receptor
antagonist NAS-181 ((R)-(+)-2-(3-morpholinomethyl-2Hchromen-8-yl)
oxymethyl-morpholine methanesulfonate...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
Proinflammatory factor mediated lymphocyte activation-the pivotal role of leukotriene B4
(2007-11-06)
-gamma
to the NK cell depleted cultures.
Further we demonstrated that leukotriene B4 (LTB4) was involved in the
effect of the PSK and Trx80. LTB4 was detected in the medium, and T cell
activation was compromised by addition of leukotriene biosynthesis
inhibitors...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Functional and diagnostic aspects on adrenocortical adenoma
(2007-04-13)
Adrenocortical tumours are frequently detected due to increased use of imaging techniques like computed tomography, magnetic resonance imaging or ultrasound. The majority of the patients have tumours that do not have any ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
.0-1.7). Mineral oil exposure was associated with a particularly high risk of developing rheumatoid factor positive RA (RR =1.4, 95% CI =1.0-2.0) and anti-citrulline positive RA (anti-CCP+RA) (RR =1.6, 95% CI=1.1-2.2). The highest risk of developing anti- CCP...
SNAP-25 and Cdk5 as exocytotic regulators : consequences for synaptic function and insulin release
(2007-04-05)
The process by which cells release substances through fusion of vesicles
with the plasma membrane is called exocytosis. Regulated exocytosis needs
to be tightly controlled in order to respond to the large variation ...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. ...