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Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. ...
Host-pathogen interactions in severe group A streptococcal infections
(2007-12-28)
Streptococcus pyogenes, also called group A Streptococcus (GAS), is an important human pathogen ranked number 9 on the list of global killer pathogens. It causes a wide spectrum of disease, including uncomplicated superficial ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Identification of the susceptibility genes in type 1 diabetes and diabetic nephropathy
(2007-11-02)
Genetic susceptibility plays an important role in the pathogenesis of
type 1 diabetes (T1D) and diabetic nephropathy (DN). The present study
aims to investigate the association between single nucleotide
polymorphisms ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
+RA (RR=1.7, 95% CI=1.1-2.6) was observed after exposure to hydraulic oil. The number of women occupationally exposed to mineral oils was too few to allow meaningful analyses. Association between cosmetic usage and the risk of developing RA was also...
Caesarean section on maternal request : personality, fear of childbirth and signs of depression among first-time mothers
(2007-05-15)
Aim: The overall aim of this thesis was to study healthy first-time mothers
requesting and undergoing an elective caesarean section (CS) and to
compare these to healthy first-time mothers planning a vaginal delivery.
The ...
Studies on the hormonal regulation of bile acid synthesis
(2007-01-05)
receptors, as well as of the rate-limiting enzyme
of BA synthesis, Cyp7a1. These findings may in part explain the elevated
plasma (particularly HDL) cholesterol levels in these animals. The Cyp7a1
response to dietary cholesterol is attenuated in ob/ob mice...
Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria
(2007-02-09)
Artemisinin (ART) class of compounds are of special interest due to their
rapid onset of action and high activity against multidrug resistant
malaria. The major drawback in monotherapy with ART and its derivatives
is ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...