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Combined oral contraceptives : impact on the vulvar vestibular mucosa and pain mechanisms
(2007-08-24)
Objective: The main aim of this thesis was to study the impact of
combined oral contraceptives (COC) on the vulvar vestibular mucosa and
pain mechanisms; in healthy women and in women with provoked
vestibulodynia (former ...
Regulation and function of the human fallopian tube
(2007-05-11)
The Fallopian tube is essential for human reproduction. Transport of the
spermatozoa, the egg, and later the pre-embryo is believed to be aided by
muscular contractions in the wall of the Fallopian tube and cilia in ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta : effects on clinical symptoms and bone turnover
(2007-10-25)
-V involve 130 children and adolescents with different types OI of which 69 were treated with bisphosphonates. Treatment was given as monthly infusions of disodium pamidronate (APD). Assessments were done according to a prospective observational study...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
the levels of the expression of phosphorylated IGF receptor type 1 (p-IGF1R), caspase-3, Bcl-2, and IGFBP-3 in Leydig cells at different stages of development. The IGF receptor type 1(IGF1R) are expressed primarily in the adult testis and IGF-I participates...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
.0-1.7). Mineral oil exposure was associated with a particularly high risk of developing rheumatoid factor positive RA (RR =1.4, 95% CI =1.0-2.0) and anti-citrulline positive RA (anti-CCP+RA) (RR =1.6, 95% CI=1.1-2.2). The highest risk of developing anti- CCP...
Transcription and transport of a messenger RNP particle : novel regulatory mechanisms
(2007-10-19)
In all living cells gene expression is a central process that involves
several steps, including transcription, processing, transport and
translation. A fine-tuning of these events is a pre-requisite for proper
cellular ...
Knowledge acquisition in patients with heart disease
(2007-09-07)
The general aim was to evaluate different aspects of the knowledge
acquisition process in patients with heart disease. Three different
education programs were evaluated.
In Paper I 208 patients with systolic heart failure ...