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Esophageal cancer surgery : factors influencing survival
(2007-01-19)
The principal aim of this thesis was to address factors that may affect
survival after esophageal cancer surgery. Surgical resection remains the
only established potentially curative treatment for patients with
resectable ...
Statistical methodology for testing genetic association in family-based studies
(2008-04-25)
This thesis is concerned with family-based studies of association between genetic markers and binary traits. A special point of interest in family-based association studies is to separate the within family correlation and ...
Ultraviolet radiation cataract development and ascorbate supplementation
(2008-05-15)
Background: Cataract is the major cause of blindness in the world, and
long-term solar ultraviolet radiation (UVR) is a major risk factor. The
pathogenesis of UVRinduced cataract is studied in various animal models
and ...
Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo
(2008-01-24)
The cytochrome P450 (P450) enzymes comprise the most important enzyme
system with regard to phase I metabolism of drugs. Induction of P450s can
result in decreased plasma concentrations of the drug itself or a
coadminstered ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
About 30,000 people in Sweden are affected by stroke each year. The
effect on physical functioning, and also consequences such as depression
and aphasia, are likely to affect not only the life of the patient, but
also the ...
Caesarean section on maternal request : personality, fear of childbirth and signs of depression among first-time mothers
(2007-05-15)
Aim: The overall aim of this thesis was to study healthy first-time mothers
requesting and undergoing an elective caesarean section (CS) and to
compare these to healthy first-time mothers planning a vaginal delivery.
The ...
The effect of chronic alcoholism on epigenetic patterns regulating gene expression and neurodegeneration in the human brain
(2007-01-12)
Chronic alcoholism causes about 3.2% of all deaths worldwide. It has an
association to about 60 different diseases and injuries with enormous
social and economical impact. Despite these facts, very few
pharmacological ...
Blood donors' long-term health : implications for transfusion safety
(2007-11-12)
Continuous attention to transfusion safety through improvement of disease
screening and donor selection has succeeded in reducing the risks of
transfusion transmitted disease to practically immeasurable levels.
Despite ...
Etiological aspects of gastroesophageal cancers : an epidemiological approach
(2007-09-14)
Aims: The aims of this thesis were to study the association of overall dietary habits, duodenal ulcer and gastric ulcer diseases, as two models of Helicobacter pylori (H. pylori) infection and the development of gastroesophageal ...
International migration and coronary heart disease : epidemiological studies of immigrants in Sweden
(2007-10-05)
In today's globalised world, with considerable international migration,
knowledge about the health of immigrants is becoming increasingly
important. In Sweden, about 13% of the population or over one million
persons are ...