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On the mind's time : production, perception, and pianists performance of rhythms : neural correlates and neuroanatomical changes
(2005-11-18)
Human movements are impressively flexible and precise. They are also coloured by the characteristics with which each person performs an act. This is evident in everyday activities, in sports, in art, and in music performance. ...
Effects of mifepristone on the human endometrium and the fallopian tube during the luteal phase
(2005-05-19)
Mifepristone given postovulatory has been shown effective for contraception, but the precise mechanism of action is still poorly understood. A better understanding of the mechanisms of action of mifepristone, when used for ...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
Maximal systolic and diastolic velocities recorded from four sites of the mitral annulus motion (MAM) reflect left ventricular (LV) performance. This thesis focus on factors influencing M-mode derived velocities in healthy ...
Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum
(2005-04-29)
ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly
conserved in mammalian species. The N-terminal domain of ERp29 is similar
to the thioredoxin domain of protein disulfide isomerase (PDI) lacking
however ...
Protein mass spectrometry in the drug discovery process
(2005-04-22)
Most targets for drug discovery are proteins. Drug discovery includes target identification and validation, structural biology, lead generation, lead optimisation, pre-clinical development and clinical trials. The overall ...
Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods
(2006-03-17)
Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular ...
Differential RNA expression in benign and malignant adrenocortical tumours
(2005-11-21)
Adrenocortical cancer is a rare but very aggressive endocrine tumor, with a yearly incidence of 0.5 to 2 cases per million inhabitants, accounting for 0.2% of all cancer related deaths. This contrasts to the high prevalence ...
Some lifestyle-related factors and risk of chronic renal failure : a population-based approach
(2005-02-11)
µmol/l (men) or 250 µmol/l (women) during the two-year study period, 1996-1998. The final study population included 926 cases and 998 randomly selected controls from the study base. A face-to-face interview and a self-administered questionnaire provided...
Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rapture
(2005-11-11)
Fragmentation of elastin, loss of smooth muscle cells (SMCs) and accumulation of inflammatory cells are the histological landmarks of abdominal aortic aneurysm (AAA). In larger aneurysms, an intraluminal thrombus is almost ...