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Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. Condensation between isatin and an alpha-amino acid yielded a cyclic intermediate, an oxazolidinone, which decarboxylate to give a 1,3-dipolar species, an azomethine ylide...
Women’s experiences of fetal screening for Down’s syndrome by means of an early ultrasound examination
(2005-03-25)
randomly allocated to the intervention group, and 996 to routine care. No statistically significant differences were found between the two groups regarding major worry about something being wrong with the baby, general anxiety and depressive symptoms in mid...
Novel insulin-like growth factor-binding protein proteases : detection and characterization
(2006-10-07)
the availability of IGFs (IGF-I and IGF-II) to their receptors. In the circulation IGFs and IGFBP-3 or IGFBP-5 can bind an acid-labile subunit (ALS) to form a high molecular mass complex, which constitutes a circulating reservoir of IGFs. Post...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
disease was 5.1-fold and 3.8-fold increased in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was about 8-fold elevated in water pipe smokers and 5-fold elevated...
Solving repeat problems in shotgun sequencing
(2006-11-02)
Shotgun sequencing is the most powerful strategy for large scale sequencing. Two main approaches exist: clone-by-clone and whole genome shotgun (WGS). In the clone-by-clone strategy, overlapping clones are amplified and ...
Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts
(2005-11-11)
inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. Enhanced expression of MMPs including MMP-1 and MMP-3 is demonstrated in gingival connective tissue of individuals with periodontal...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...
The family triad : the interaction between the child, its mother, and father from birth to the age of 4 years old
(2006-10-06)
the child was 3, 9, 18, and 48 months of age. The study is part of an international collaboration to describe the development of triadic interaction in four groups: 20 Swiss German-speaking families, 20 Swiss French-speaking families, 20 American families...
Tobacco smoking and vertical periodontal bone loss
(2005-05-18)
revealed a right - left hand side symmetry. Cigarette smoking was significantly associated with the prevalence and severity of vertical bone defects (Studies II and III). The relative risk associated with current smoking was 2 to 3-fold increased...
Novel methods for the identification of cellular S-glutathionylated proteins and sites of glutathionedependent modification using affinity chromatography and proteomic analyses
(2005-02-21)
Reactive oxygen species (ROS) are formed during normal respiration in the mitochondria through electron leakage to oxygen. During normal metabolism, several enzymes and low-molecular weight antioxidants work towards ...