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Pharmacokinetics and dynamics of atovaquone and proguanil (Malarone®)
(2004-09-17)
with ketoconazole or rifampicin. Atovaquone
appears to alter the PK of proguanil and cycloguanil at steady state
after multiple daily doses of Malarone® in healthy individuals. In vitro
enzyme kinetics experiments suggest inhibition of catalytic activity of
CYP3A4...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of chemical mediators, which by different means control, maintain and resolve the process. One group of such mediators is the leukotrienes, among which LTB4 is found. LTB4 has several immunomodulating properties and mainly acts by recruiting leukocytes...
A study on the TFIID subunit TAF4
(2005-01-14)
gene expression was enriched in the central nervous system and the expression pattern showed clear spatial and temporal variations. In addition, reporter assays using transient transfections of TAF4 in cell lines indicated that TAF4 could act as a...
Processing, stability and interactions of lung surfactant protein C
(2005-11-23)
Mature SP-C is a 4.2 kDa transmembrane protein which is uniquely expressed in the alveolar type II cell. Human SP-C is generated via multistep proteolytic cleavage of both the C-terminal and Nterminal regions of proSP-C. The function of SP-C in vivo...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
of periodontal bone loss of more than 30% of the root length was 3.5-fold and 4.3-fold elevated in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was 7.5-fold elevated in water...
Formyl-coenzyme : a transferase, structure and enzymatic mechanism
(2004-08-20)
Background: Formyl-CoA transferase (Frc) is the first enzyme in a two
enzyme pathway responsible for oxalate degradation in Oxalobacter
formigenes. This bacterium is a constitutive part of human intestinal
flora. Its ...
The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia
(2006-02-22)
Vascular inflammation is a hallmark of major cardiovascular diseases such as atherosclerosis, and also suggested as a critical component implicated in intimal hyperplasia. Given its central role in regulating expression ...
Studies on apolipoprotein E and high cholesterol diet as risk factors for neurodegeneration
(2005-12-30)
linked to many other forms of neurodegeneration. The mechanisms by which apoE4 increases the risk for neurodegeneration are largely unknown, but it has been hypothesised that apoE4 may have a deficient function compared with other isoforms. In general...
Physical fitness and overweight in Swedish youths
(2005-03-22)
The aim of the present thesis was to describe the level of physical fitness and prevalence of overweight and obesity in Swedish youths, and their trends over 14 years. Additionally, the relation between fitness and overweight ...