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Now showing items 1-10 of 78
Sentinel node biopsy in breast cancer : aspects on validation, diagnostics and lymphatic drainage pattern
(2006-10-06)
with prior intervention were included. The detection rates were 95.3% (710/745) and 90.7% (78/86), respectively. During the follow-up time of almost 2 years, no axillary relapse was found among the 103 patients with a positive SLN that was followed by ALND...
Perinatal and familial risk factors of youth suicidal behaviour
(2005-10-28)
study design in Study II and III, including 713,370 individuals in Study II and 318,953 males in Study III. In paper IV all individuals, who were born 1968-80 and who had attempted suicide (14,440 cases) until 1999 were matched for gender, county...
Spontaneous abortion : risk factors and measurement of exposures
(2006-09-22)
The overall objectives of this thesis were to increase the understanding of the etiology of spontaneous abortion and repeated spontaneous abortion, and to evaluate possibilities of exposure assessment during pregnancy.
Data ...
Molecular studies of complications in end stage renal disease : focus on expression and variations of candidate susceptibility genes
(2005-09-09)
End stage renal disease (ESRD) is a complex multifactorial disorder, where both environmental and genetic factors are contributing to the phenotype. The most common complications seen in ESRD patients are malnutrition, ...
Physical activity in rheumatoid arthritis
(2006-04-28)
Physical activity confers health benefits in the general population and should also be applied to people with rheumatoid arthritis (RA). However, there is a need for more research in this area. The aim of this thesis was ...
Aspects on the modulation of potassium channels in insulin-producing beta-cells
(2006-10-27)
This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits ...
Differential RNA expression in benign and malignant adrenocortical tumours
(2005-11-21)
Adrenocortical cancer is a rare but very aggressive endocrine tumor, with a yearly incidence of 0.5 to 2 cases per million inhabitants, accounting for 0.2% of all cancer related deaths. This contrasts to the high prevalence ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Apoptosis in the myelodysplastic syndromes : protective effect of G-CSF
(2005-09-23)
Increased apoptosis of hematopoietic progenitor cells is a hallmark for
the myelodysplastic syndromes (MDS), and one of the main reasons for the
ineffective hematopoiesis and subsequent cytopenia characteristic for ...
Inflammatory status in adolescents : the impact of health determinants such as overweight and fitness
(2006-03-07)
Overweight prevalences are rising among youth and the prevention of associated chronic diseases is priority concern in public health. Inflammatory processes are involved in the pathogenesis of cardiovascular diseases and ...