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Modulation of the deubiquitnating system during lymphoid cell activation and viral infection
(2005-08-15)
The family of ubiquitin-specific proteases (USPs) removes ubiquitin from its conjugates and regulates the production and recycling of ubiquitin. USPs are thereby critically involved in the control of important functions ...
Protein mass spectrometry in the drug discovery process
(2005-04-22)
Most targets for drug discovery are proteins. Drug discovery includes target identification and validation, structural biology, lead generation, lead optimisation, pre-clinical development and clinical trials. The overall ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Influence of genetic polymorphisms on DNA repair, p53 mutations and cancer risk
(2006-09-29)
Individuals have different susceptibility towards environmental exposures that may cause or contribute to disease. This inter-individual variation is partly due to genetic polymorphisms in genes involved in DNA repair and ...
Physical activity, body composition and physical self esteem among children and adolescents
(2005-02-25)
The increasing prevalence of overweight and obesity poses a global health problem. Special concern is focused on overweight during youth since it may cause negative impact on health both during childhood, adolescence and ...
Developmental role and ligand binding properties of macrophage scavenger receptor MARCO
(2006-08-11)
Macrophages express several cell surface receptors, that mediate the recognition of a wide range of endogenous and exogenous ligands. In this manner, macrophages are able to perform their multiple biological functions in ...
Xenobiotics-induced phosphorylations of MDM2
(2006-11-24)
The aim of the present study was to characterize the Mdm2 and p53 responses induced by DNA damaging xenobiotics and how these responses can be modified by non-genotoxic xenobiotics. During control conditions cellular levels ...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...
Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum
(2005-04-29)
ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly
conserved in mammalian species. The N-terminal domain of ERp29 is similar
to the thioredoxin domain of protein disulfide isomerase (PDI) lacking
however ...
Enhancing survival of mothers and their newborns in Tanzania
(2005-05-06)
General aims: The main purpose of the present studies was to examine the problem of maternal and perinatal mortality in an upcountry region of a low-income country. This was done by estimating the magnitude of maternal and ...