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Immunological and virologica response to antiretroviral treatment (art) in patients infected with different HIV-1 genetic subtypes
(2006-02-17)
months of treatment, while the corresponding figures for Caucasians and Asians were 91% and 100%, respectively. We found a good short-term virological outcome of ART in a cohort of ART-naive patients of diverse ethnic background infected with different...
Follow-up studies of the obstetrical brachial plexus injury
(2006-09-15)
Aims: The overall aim of these studies were to investigate the influence of different kinds of treatment of the obstetrical brachial plexus lesion, and to study functioning and participation in adolescents with ...
Prevention of complications in pediatric cataract surgery
(2004-11-26)
This thesis was performed to find ways to lessen the complications to pediatric cataract surgery, which is an increasingly safe procedure, also in infants. However, there are some complications to the surgery, which threatens ...
Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases
(2006-09-15)
The deoxyribonucleoside kinase of the fruit fly Drosophila melanogaster (Dm-dNK) is a multisubstrate enzyme that phosphorylates pyrimidine and purine deoxyribonucleosides as well as several anticancer and antiviral nucleoside ...
Patient-orientated aspects of the postoperative course after hernia surgery
(2006-09-01)
Operations for inguinal hernia are one of the most common surgical procedures performed. With the development of mesh techniques, recurrence rates have improved radically and patient-orientated endpoints have evolved as ...
Interaction between waterborne pathogenic bacteria and Acanthamoeba catellanii
(2005-12-30)
Waterborne bacteria cause global public health problems. Francisella tularensis causes tularemia, which is a fatal disease in humans. Pseudomonas aeruginosa is an opportunistic and nosocomial pathogen of humans. Vibrio ...
Psoriasis : studies of phenotype at onset and of associated cardiovascular morbidity
(2005-08-12)
Psoriasis is a complex inflammatory skin disorder, affecting 2-3% of the population in the western world. The etiology of psoriasis is not yet known. However it is likely that its pathogenesis involves interplay between ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
B. subtilis, A. aeolicus and a designed mutant LS from A. aeolicus (structure determined by cryo-EM in manuscript IV) were studied using small angle x-ray scattering (SAXS) and cryo-EM. The results indicate that multiple assembly states are a general...
Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9
(2005-09-09)
as in yeast microsomes with recombinantly expressed CYP2C9 variants. The formation rate of OH-celecoxib was significantly reduced in CYP 2C9*3 samples, compared to samples with two functional alleles. The CYP2C9*2-samples did not differ from CYP2C9*1 in any...
Life situation after stroke : the spouses' perspective
(2005-09-23)
In Sweden approximately 30,000 people suffer from stroke every year, of which some 20,000 for the first time. The disease is one of the most disabling chronic diseases in the adult population, with severe consequences for ...