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Immunomodulation in atherosclerosis : impact of Th balance and CD1d-restricted NKT cells
(2004-11-05)
lipid antigens presented by the CD I molecules. After
activation, the NKT cell secretes large amount of both IFNgamma and IL-4.
Upon activation, naïve CD4+ T cell, can follow two different pathways of
differentiation and become either Th1 or Th2 cells...
Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9
(2005-09-09)
) of the CYP2C9 probe drug losartan was found in volunteers genotyped as CYP2C9*1/*3 compared to CYP2C9*1/*1 subjects (p<0.05), even though there was considerable variation within each genotype group. The subjects homozygous for the CYP2C9*3 allele had...
Cholinergic receptors in human prenetal brain : presence, distribution and influence of nicotine and ethanol
(2005-03-18)
Events early in life, including exposure to various compounds, may cause
disturbances in brain development. Both maternal smoking and alcohol
drinking during pregnancy can induce preand postnatal death, cognitive
and ...
A study on the TFIID subunit TAF4
(2005-01-14)
gene expression was enriched in the central nervous system and the expression pattern showed clear spatial and temporal variations. In addition, reporter assays using transient transfections of TAF4 in cell lines indicated that TAF4 could act as a...
Ethyl glucuronide : a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results
(2006-02-17)
In recent years, there has been a growing interest in various biochemical markers for detecting acute and chronic alcohol consumption. Biochemical markers for acute and chronic drinking play important roles in detecting ...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
, both 5HT2AR, being CD3, CD4 or CD8 positive cells, and serotonin transporter protein (SERT) positive cells, being CD1a, CD4, CD8 positive or CD56+ CD3- cells, were increased. 5-HT3R immunoreactivity was seen in the basal epidermis of the inflamed...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
of both CYP2C9 (4.9-fold increase in the urinary losartan/E3174 ratio; 95% CI 2.8 - 8.4) and CYP2C19 (3.6-fold increase in the plasma omeprazole/5-hydroxyomeprazole ratio; 95% CI 2.6 - 4.8) was seen during noscapine treatment. This is likely to explain...
Functional studies on the interaction of immunoglobulins with HIV-2 envelope
(2005-09-16)
for both HIV- 1 and HIV-2. However, studies have indicated that this site is not exposed in HIV- 1 primary isolates. To study the exposure of the V3 region, both functionally and structurally, the envelope gene from a primary CD4-independent HIV-2 isolate...