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Born too small or too early : effects on blood pressure, renal function and retinal vascularization in adulthood : experimental and clinical studies
(2004-11-12)
Background: Several epidemiological studies the past fifteen years have
suggested a connection between fetal growth retardation and later effects
on adult health, such as an increased arterial blood pressure and type 2
diabetes mellitus. We studied...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Coronary artery bypass surgery without extracorporeal circulation
(2006-03-10)
Introduction: Coronary artery bypass surgery with extracorporeal circulation is associated with a systemic inflammatory response syndrome that contributes to morbidity and mortality. Aortic cross clamping and cardioplegic ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Novel methods for the identification of cellular S-glutathionylated proteins and sites of glutathionedependent modification using affinity chromatography and proteomic analyses
(2005-02-21)
-glutathionylated proteins under non-reducing conditions, in an attempt to avoid the cumbersome 2-D gel electrophoresis step and at the same time identify the sites of S-glutathionylation by tandem mass spectrometry. The glutathionylation sites of gamma-actin, heat...
Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes
(2006-04-07)
One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin resistance are for example...
The role of Nkx proteins neuronal and glial specification
(2004-11-12)
) are sequentially generated from a domain defined by the expression of Olig2. We show that the generation of sMNs and OLPs in the ventral spinal cord is essentially missing in mice lacking Nkx6 function. In contrast, the same HD proteins instead act to suppress OLP...
Neural mechanisms underlying working memory : computational and neuroimaging studies
(2006-09-08)
The performance on various cognitive tasks, from language to selective attention and guidance of future actions depends on working memory (WM), the ability to hold and manipulate limited items of information for a period ...
HIV-2 genetic evolution and viral dynamics
(2006-05-03)
HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In this thesis we have...
Long-term neurodevelopmental outcome after moderate neonatal encephalopathy and after post-term birth : two population-based studies
(2006-03-17)
Long-term neurodevelopmental outcome in two population-based groups of children with different perinatal events was studied: A) Children born at term with moderate neonatal encephalopathy (NE) and B) children born post-term ...