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Sentinel node biopsy in breast cancer : aspects on validation, diagnostics and lymphatic drainage pattern
(2006-10-06)
to 80.9%, whereas the addition of intraoperative IC examination did not affect the results. The sensitivity of intraoperative frozen section for micrometastases was 35% with H&E staining, 45% with MC and 55% with IC (paper II).
In a study including 30...
The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9
(2004-11-16)
combinations of CYP2C9*1, 2C9*2 and 2C9*3. Overall, the plasma clearance of S-PPC was moderately reduced in CYP2C9 variant allele carriers, while RPPC clearance was essentially unaffected. However, the metabolite formation clearances were impaired in a gene...
Regulation of gene and protein expression : two model systems
(2005-11-25)
Genetic information is expressed by DNA transcription and mRNA translation. With few exceptions, every cell of an organism, or the human body, contains the same genetic information. Yet the structure and function of different ...
Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors
(2005-04-01)
Modem cataract surgery with implantation of an intraocular lens (IOL) is an increasingly safe and successful procedure, though complications still occur. This thesis addresses the most common complication, posterior capsule ...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
Background & Aim: Tobacco smoking exerts a harmful effect on the periodontal tissues manifested by periodontal pockets, attachment loss and periodontal bone loss. Current evidences on the effects of tobacco on periodontal ...
Human salmonellosis : impact of travel and trade from a Swedish perspective
(2006-09-08)
of import rules, but also how this trend could be broken by active information. In Paper II, we showed the risk of travel-associated salmonellosis to be highest in East Africa and the Indian subcontinent. Children aged 0-6 years were at higher risk than...
Follow-up studies of the obstetrical brachial plexus injury
(2006-09-15)
was significant and indicates a better range of shoulder motion after nerve reconstruction. The time of the operation, whether it took place before or after 6 months of age, did not influence the result. A decrease in grip strength and bimanual function was found...
Renal cell death in urinary tract infections : role of E. coli toxins
(2005-01-28)
) inhibited O6-toxin(s)-induced cell death. Furthermore, incubation with a metabolite of HO-1, carbon monoxide, could counteract the effects of E.coli-toxins. The protection by carbon monoxide was associated with up-regulation of p21 protein expression...
Studies on alcoholic liver disease
(2006-11-17)
The overall aim of this thesis was to explore the impact of alcoholic cirrhosis in Sweden, and the relation between drinking patterns and beverage types and alcoholic cirrhosis, and to evaluate the possible role of ...
Pituitary autoantibodies in endocrine disorders
(2005-09-30)
by immunoblotting. Reactivity to a M, 49 000 pituitary autoantigen was significantly more frequent in patients with idiopathic pituitary hormone deficiency (6/21 (28%) p< 0.05) as well as their relatives (10/35 (28%) p<0.02) compared to control subjects (3/44 (6...