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Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
), Presenilin 1 (PSEN1), and Presenilin 2 (PSEN2) have been described to cause the early-onset familial form of AD. However, the discovery of genes involved in sporadic late-onset AD has proven to be more difficult. Apolipoprotein-E (APOE) which mediates lipid...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
of 1-4 and 5-9 years of age and for three out of seven geographical regions. Based on the first 100 ICF, recall was acceptable in 90% of the interviews, successful identification of special events in 84%, good recovery of pesticide names, frequency...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
disease was 5.1-fold and 3.8-fold increased in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was about 8-fold elevated in water pipe smokers and 5-fold elevated...
HLA and KIR gene polymorphism in hematopoietic stem cell transplantation
(2006-09-01)
The major histocompatibility complex (MHC) in humans known as the Human Leukocyte Antigens (HLA) is localised to the short arm of chromosome six. The HLA class 1 antigens, HLA-A, -B and -C are highly polymorphic glycoproteins expressed on the cell...
Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes
(2004-10-29)
of the locomotor rhythm induced by NMDA in the isolated lamprey spinal cord preparation. This increase in the frequency is the result of a number of cellular and molecular mechanisms that have been studied in detail. Firstly, mGIuR1 potentiates the NMDA...
Studies on mesothelial differentiation : prognostic and therapeutic approaches to malignant mesothelioma
(2005-09-30)
Malignant mesothelioma (MM), a tumor with a poor prognosis, causes the death of most patients within a year of diagnosis since various treatments seem to have little effect on its outcome. The biological behavior of MM ...
HIV-2 genetic evolution and viral dynamics
(2006-05-03)
HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In this thesis we have...
Pain and physical activity in rheumatoid arthritis : a cognitive approach in physical therapy
(2005-05-06)
A gradual shift towards more active patient involvement has taken place during the past few decades. It is thus important for physical therapists to understand individuals’ cognitive appraisals of health states. Patients ...
Anxiety, exhaustion and depression in relation to periodontal diseases
(2006-03-10)
in non-smokers and smokers (Study I). Secondly we wanted to determine if self-reported anxiety had an association with gingival inflammation and attachment level (AL), as well as with the levels of prostaglandin E2 (PGE2), interleukin 1beta (IL-1beta...
Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods
(2006-03-17)
Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the ...