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Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(2004-09-03)
c, Bid and Bax, as well as up-regulation of genes involved in erythroid differentiation (beta-globin, GATA-1 and DLK-1) in MDS CD34+ cells. Beta-globin was adequately expressed during erythroid maturation, while GATA-1 expression was significantly...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
and GLP-1 on gastric emptying, metabolic control and appetite after intake of a mixed meal in man. In addition, I (3) studied the effects of ghrelin on smooth muscle contractility in rat and (4) its effect on gastric emptying in humans after intake of a...
Peptic ulcer disease in an adult population : the Kalixanda study – a population-based endoscopic study
(2006-12-21)
Introduction: The pattern of symptoms and perception of disease among
patients seeking care does, due to health care seeking behaviour, most
probably not reflect the true health status in the general population.
Upper ...
Apoptosis in the myelodysplastic syndromes : protective effect of G-CSF
(2005-09-23)
Increased apoptosis of hematopoietic progenitor cells is a hallmark for
the myelodysplastic syndromes (MDS), and one of the main reasons for the
ineffective hematopoiesis and subsequent cytopenia characteristic for ...
Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs
(2005-05-13)
), thereby amplifying cAMP/PKA-mediated responses. Haloperidol also stimulates the phosphorylation of the two mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases 1 and 2 (Erk1/2). In addition, haloperidol phosphorylates...
Preoperative staging and radiotherapy in rectal cancer surgery
(2006-09-29)
preoperative endorectal ultrasound staging of 545 patients with rectal tumors were compared with postoperative pathoanatomical staging. From 1980 through 1993, 1 406 patients were randomly assigned to either preoperative (5x5 Gy) radiotherapy and surgery...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
disease was 5.1-fold and 3.8-fold increased in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was about 8-fold elevated in water pipe smokers and 5-fold elevated...
Predicting transmembrane topology and signal peptides with hidden Markov models
(2006-03-17)
Transmembrane proteins make up a large and important class of proteins. About 20% of all genes encode transmembrane proteins. They control both substances and information going in and out of a cell. Yet basic knowledge ...
Amyloid precursor protein : cellular studies and animal models
(2006-09-12)
. This APP signalling did not require γ-secretase cleavage, as it was independent of the presence of presenilin-1 and -2. In paper II, we investigated the localisation and levels of ODC protein in AD brain. Specifically, we examined the ODC immunoreactivity...
Genital mutilation of girls in Sudan : community- and hospital-based studies on female genital cutting and its sequelae
(2005-04-19)
for age, education, socio-economy, and sexually transmitted infections, cases with primary infertility had a significantly higher risk than referents of having undergone the most extensive form of FGM involving labia majora (OR 4.69; 95% CI 1.49, 19...