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Identification of new proteins and biological processes in the apicomplexan Toxoplasma gondii
(2006-11-20)
The apicomplexan protozoan Toxoplasma gondii is a ubiquitous parasite of humans and animals. Entering its host through the digestive system, it possesses the ability to rapidly disseminate in the body and infect a wide ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
positive epicutaneous patch test reactions, at 72h, an increased number of GAP43 immunoreactive nerve fibres were found in the eczematous compared to control skin. Semiquantification showed an increase in dermal substance P and its neurokinin 1 receptor...
Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) : implications for nasopharyngeal carcinoma
(2005-05-19)
which enable the virus to efficiently immortalize B lymphocyte and also transform cells of other types. Among the viral genetic products, a membrane integral latent infection protein, latent membrane protein-1 (LMP1) is of particular interest, since...
Reasons for non-vaccination
(2006-05-25)
Vaccines are among the most effective public health interventions used today. Population based vaccination programmes are mainly aimed at protecting against common childhood diseases, but other population groups are also ...
Urinary tract infection and renal scarring
(2006-08-18)
destruction and proper healing after infection. If too high levels of TIMP-1 are produced during acute inflammation, renal scar will develop more probably. We indicated that the pro-scarring effect of TIMP-1 could be explained by its complex action during...
Nephrin-mutations in congenital nephrotic syndrome of the Finnish type and cell lineage specific gene regulation
(2005-04-21)
of kidney and brain specific regulatory elements in the region -4 kb; -2.1 kb (where the first nucleotide of the ATG codon of nephrin is +1). The sequence between -1.9 and -1.2 kb was found to be important for spinal cord and pancreas expression...
Aspects on the modulation of potassium channels in insulin-producing beta-cells
(2006-10-27)
ratio ≤ -0.5) by diazoxide. 86% of diazoxide's effects (up and down regulation) were observed only after co-culture with 27 mmol/1 glucose. Up-regulation was to 3 1 % and down-regulation to 79 % contrary to effects of glucose per se. Diazoxide down...
Protein mass spectrometry in the drug discovery process
(2005-04-22)
with other biophysical techniques to characterize how pyridazine analogues inhibit protein tyrosine phosphatase 1B (PTP1B). PTP1B is a drug target for non-insulin dependent diabetes mellitus and obesity. This study showed that pyridazine analogues inhibit PTP...
Novel methods for the identification of cellular S-glutathionylated proteins and sites of glutathionedependent modification using affinity chromatography and proteomic analyses
(2005-02-21)
Reactive oxygen species (ROS) are formed during normal respiration in the mitochondria through electron leakage to oxygen. During normal metabolism, several enzymes and low-molecular weight antioxidants work towards ...