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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
-PSOX, which mediates uptake of oxidized low-density lipoprotein (oxLDL) by cells. We detected abundant CXCL16/SR-PSOX and CXCR6 expression in atherosclerotic lesions from human subjects and apolipoprotein-Edeficient (ApoE-/-) mice. In monocytes, CXCL16/SR...
Fusion activation in murine leukemia virus
(2006-04-21)
This thesis describes the fusion activation in Murine leukaemia virus (MLV). During entry of retroviruses into uninfected cells, the viral and cellular membranes fuse. The fusion process is mediated by the viral envelope ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
Background: Leukemias are the most common childhood cancers, accounting for 25-35% of the incidence of all childhood cancer in most populations. In early reports on cancer, Costa Rica ranks among the highest incidence of ...
Molecular studies of complications in end stage renal disease : focus on expression and variations of candidate susceptibility genes
(2005-09-09)
) and C-reactive protein (CRP) are highly elevated in ESRD patients and predict mortality in both healthy and uremic individuals. Hence putative SNPs that may regulate plasma levels of these proteins were investigated (IL-6 SNPs: -597G/A, -174G/C, 5014A...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
Prevention of complications in pediatric cataract surgery
(2004-11-26)
This thesis was performed to find ways to lessen the complications to pediatric cataract surgery, which is an increasingly safe procedure, also in infants. However, there are some complications to the surgery, which threatens ...
Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum
(2005-04-29)
ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly
conserved in mammalian species. The N-terminal domain of ERp29 is similar
to the thioredoxin domain of protein disulfide isomerase (PDI) lacking
however ...
Psoriasis : studies of phenotype at onset and of associated cardiovascular morbidity
(2005-08-12)
Psoriasis is a complex inflammatory skin disorder, affecting 2-3% of the population in the western world. The etiology of psoriasis is not yet known. However it is likely that its pathogenesis involves interplay between ...
On the development of postural adjustments in sitting and standing
(2006-10-27)
We have studied postural adjustments, i.e., muscle activity elicited by external perturbations in typically developing infants during the periods in life when independent sitting and standing emerge. We also studied two ...