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Development of a vaccine against strangles
(2005-09-16)
Strangles is an acute upper respiratory tract disease in the horse, which is characterized by purulent pharyngitis and lymphadenitis. It is caused by Streptococcus equi subsp. equi. The severe suffering and economical ...
Renal cell death in urinary tract infections : role of E. coli toxins
(2005-01-28)
Febrile urinary tract infections (UTI) are common bacterial illnesses in children. Several follow up studies have shown that 10-15 % of infants with pyelonephritis will develop permanent renal damage, i.e., renal scars, ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
transcription of the Necdin promoter and that TH repressed this activation. We further showed that TR bound as a heterodimer with Retinoic-X-receptor (RXR) to the Necdin nTRE sequence and that RXR and the nuclear receptor corepressor (NCoR) enhanced the TR...
Apoptosis in the myelodysplastic syndromes : protective effect of G-CSF
(2005-09-23)
Increased apoptosis of hematopoietic progenitor cells is a hallmark for
the myelodysplastic syndromes (MDS), and one of the main reasons for the
ineffective hematopoiesis and subsequent cytopenia characteristic for ...
Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue
(2005-10-07)
The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival ...
Children with high and intermediate imperforate anus : aspects of care and psychosocial effects of the malformation
(2005-10-21)
The overall aim of this thesis was to investigate the experiences of
children with high and intermediate imperforate anus and of their
parents; how they have experienced care and treatment and what
consequences the ...
Cholinergic receptors in human prenetal brain : presence, distribution and influence of nicotine and ethanol
(2005-03-18)
Events early in life, including exposure to various compounds, may cause
disturbances in brain development. Both maternal smoking and alcohol
drinking during pregnancy can induce preand postnatal death, cognitive
and ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
B. subtilis, A. aeolicus and a designed mutant LS from A. aeolicus (structure determined by cryo-EM in manuscript IV) were studied using small angle x-ray scattering (SAXS) and cryo-EM. The results indicate that multiple assembly states are a general...
Chemical, pharmacokinetic and biological aspects of platinum-based drugs
(2005-05-06)
The use of cisplatin for the treatment of metastatic testicular cancer is a medical historical landmark given that, for the first time, patients could be cured with drug therapy. A third generation platinum-based drug, ...