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Psychosocial situation of parents of children with congenital heart disease
(2004-12-31)
Background: Current knowledge of the psychosocial situation of parents of congenital heart disease children (PCCHD) should be interpreted with caution. Most studies may not be representative of the population in question, ...
Colon cancer : disease related proteins in tumor tissue and serum
(2004-11-19)
Despite the progress in surgical techniques and adjuvant therapies the
mortality of around 60% within the group of colon cancer patients did not
decrease significantly over the last decades. This determines a growing
demand ...
Genome instability, gene expression and prognosis in breast cancer
(2005-02-18)
Aneuploid cancers are regarded as being more malignant than tumors of other ploidy categories, and they are characterized by increased genomic instability. Our investigations resulted in the characterization of an aneuploid ...
Synovial sarcoma : molecular, biological and clinical implications
(2004-08-13)
Synovial sarcoma is a rare but mostly aggressive soft tissue tumor that mainly affects children and young adults. The tumor usually occurs in the vicinity of large joints, and may be subdivided into a classical biphasic ...
Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia
(2006-08-25)
Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult ...
Ante partum determination of lactate in amniotic fluid
(2005-05-06)
concentrations (< 4.5 mmol/l). Among women with "high" lactate concentrations 76 (88%) started in labour within 24 hours, as compared with 20 (21%) for those with "low" lactate concentration, giving an Odds Ratio (OR) of 27.7; 95% C.I. 12-63.3.
Conclusion...
Studies on growth hormone induced female-characteristic gene transcription in rat liver
(2005-05-06)
Growth hormone (GH) secretion is sexually dimorphic, which has an impact on hepatic gene expression. This is particularly pronounced in rats but has also been demonstrated in other species, including humans. The male GH ...
Development of AIDS associated and endemic Kaposi sarcoma : HHV-8/KSHV viral load in cutaneous and oral tumor cells
(2006-09-05)
and late KS, suggesting a continuous recruitment of noninfected endothelial cell into the KS lesion; (c) LANA+/CD34- cells decrease from early 18.7% to late 29% and most of them expressed LEC markers such as LYVE-1 and D2-40, suggesting that the resident...
Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study
(2005-11-18)
-EpCAM mMAb alone (54% vs 15%) as well as PFS (15 vs 7 weeks). Clinical effects were mainly stable disease > 3months (11 of 14 responders) and responding patients survived longer than non-responders. The clinical efficacy of antiEpCAM cMAb and GMCSF...
Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes
(2004-11-12)
-inducible subunits of the proteasome, LMP2, LMP7 and MECL-1, the transporters associated with antigen presentation (TAP) and MHC class I heavy chain. These changes resulted in increased stability of surface MHC class I complexes, presumably due to an increased supply...