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On mapping the human somatosensory cortex : fMRI and PET imaging
(2004-08-26)
the BOLD response in 10 subjects whilst passively discriminating various parallelepiped objects presented to their right hand or foot. Separate representations of hand and foot activations should represent somatotopical organisation. Areas 3a, OP2 and OP3...
Physical capacity in individuals with cerebral palsy : problems, needs and resources, with special emphasis on locomotion
(2005-09-09)
). The individuals were in four tests instructed to walk as far as possible for six minutes. The distance walked, heart rate and perceived exertion were assessed. The walked metre averaged 316 (range 74-579), 336 (range 65621), 341 (range 83-626) and 345 (range 88...
Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
(2006-01-20)
A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. Condensation between isatin and an alpha-amino acid yielded a cyclic intermediate, an oxazolidinone, which decarboxylate to give a 1,3-dipolar species, an azomethine ylide...
Opioid and non-opioid activities of the dynorphins
(2005-12-30)
Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts
(2005-11-11)
inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. Enhanced expression of MMPs including MMP-1 and MMP-3 is demonstrated in gingival connective tissue of individuals with periodontal...
Off-label drug treatment and related problems in children : a register-based investigation
(2006-04-21)
Introduction: There is a lack of pediatric documentation concerning efficacy and safety of many drugs, which may contribute to off-label drug treatment and increase the risk for adverse drug reactions (ADRs).
Aims: ...
Application of two fluorescence methods for detection and quantification of smooth surface carious lesions
(2006-05-17)
Early diagnosis of carious lesions is a key factor in prevention and management of dental caries. With non-invasive, quantitative diagnostic methods it should be possible to detect lesions at an initial stage and subsequently ...