Search
Now showing items 1-10 of 100
Algorithms for building and evaluating multiple sequence alignments
(2006-09-05)
The alignment of biological sequences is crucial for the transfer of annotation from model organisms to humans. Pairwise alignment of sequences can reveal homology while multiple alignments are used to characterize protein ...
The role of red blood cells in inflammation and remodeling
(2004-08-27)
. This was supported by increased activity of MMP-1, - 2 and 3 in gel culture supernatants.
Both RBCs and RBC-CM were able to stimulate fibroblast release of interleukin-8 (IL-8), a chemoattractant for neutrophils. The pro-inflammatory cytokines interleukin-1beta...
Biophysical studies on aggregation processes and amyloid fibrils with focus on Alzheimer's disease
(2004-08-13)
Alzheimer's disease (AD) is a fatal neurodegenerative disease, and is the most common form of dementia, affecting 1-2% of the population in industrialized countries. It is believed that intermediate species formed during ...
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(2004-09-03)
55 patients were used in the experiments. RA and RARS cells showed significantly higher spontaneous initiator (caspase-8 and -9) and effector (caspase-3-like) activities than normal bone marrow (NBM). G-CSF inhibited Fasinduced caspase activity...
Organohalogen environmental pollutants in Baltic fish : chemical characterization and toxicological evaluation with a focus on bone disturbances
(2005-10-28)
and to perform a traditional subchronic toxicity study in female rats at dose levels, corresponding to 8, 40 and 160 times the estimated human intake of fish in the Swedish population. The fractionation of herring oil resulted in substantial reduction of most...
Bibliometrics as a research assessment tool : impact beyond the impact factor
(2006-10-27)
. In the different studies bibliometric indicators are calculated based on 24 223 (I), 62 104 (II) 6 142 055 (III) and 596 (IV) publications. To assess the validity of bibliometric indicators calculated using the Cl, these are combined with data from PubMed (I...
Fat mass, adipokines and clinical complications of chronic kidney disease
(2006-05-26)
Patients with chronic kidney disease (CKD), irrespective of initial etiology, have a risk of cardiovascular morbidity (CVD) and mortality that is many-fold higher than that of a similar person without CKD. While traditional ...
Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae
(2006-04-07)
A few years ago, most strains of Neisseria gonorrhoeae were susceptible to ciprofloxacin, but after introduction as a first line therapy, resistant strains emerged. Ciprofloxacin inhibit two enzymes necessary for DNA ...
New techniques in liver surgery
(2006-01-20)
The development of liver surgery has a long history and through the years, much knowledge has been gathered concerning various aspects of the liver. The exploration and understanding of liver anatomy and liver regeneration ...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis in vivo. The following...