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Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole
(2005-11-24)
]imidazo[4,5-b]pyridine and the sulfur analogue to the cooked-food mutagen IFP, 2-amino- 1,6-dimethylthieno[2,3-e]imidazo[4,5-b]pyridine.
Attempts were made to form three thienoimidazo[4,5-b]pyridines via stepwise condensation. The first condensation...
Nutritional status and cognitive function in frail elderly subjects
(2004-08-13)
. Objective measures of nutritional status and cognitive function in the residents was not changed at 5- and 6-months follow-ups, whereas SGA appeared to improve after the educational intervention (II). The combined intervention in study III resulted in a...
Exercise and angiogenic growth factors in human skeletal muscle
(2005-05-20)
Long-term electrical stimulation and endurance exercise increase the amount of capillaries in skeletal muscle. VEGF-A is a well-characterized stimulatory angiogenic growth factor and has shown to play an important role in ...
Human cytomegalovirus (HCMV) infection in patients with inflammatory bowel diseases (IBD) : role in pathogenesis and autoimmunity
(2004-11-19)
% of patients with
UC and in 100% of patients with CD. Cells double stained for HCMV and
IL-6 were detected i n intestinal tissue sections in 77% of patients with
UC and in 100% of patients with CD. These observations suggest that an
active HCMV infection...
Molecular studies of complications in end stage renal disease : focus on expression and variations of candidate susceptibility genes
(2005-09-09)
) and C-reactive protein (CRP) are highly elevated in ESRD patients and predict mortality in both healthy and uremic individuals. Hence putative SNPs that may regulate plasma levels of these proteins were investigated (IL-6 SNPs: -597G/A, -174G/C, 5014A...
On the genetic variation of interleukin-6 in health and coronary heart disease
(2005-03-18)
of IL-6 in healthy subjects and patients with CHD are largely unknown and remain to be defined. Thrombosis underlies most of the acute manifestations of CHD including myocardial infarction. The causes of thrombosis are not fully clear, but an important...
Diagnostic tests for adiposity and metabolic risk factors in adolescence : results from the Stockholm weight development study (SWEDES)
(2005-03-25)
Background: Despite growing concern about the development of pediatric
obesity, there is still controversy about its classification.
International classification systems have been proposed and national
systems are in ...
Inflammation and neurodegeneration in mouse nervous system : experimental application
(2006-01-26)
BL/6 mice resulted in neurodegeneration in area CA3 of hippocampus. Enhanced FAS and glial fibrillary acidic protein (GFAP) expression in hippocampus of mice was detected on day 7 after KA administration by immunohistochemistry and Western blotting...
Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes
(2004-10-29)
The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and ...
Prevention of complications in pediatric cataract surgery
(2004-11-26)
This thesis was performed to find ways to lessen the complications to pediatric cataract surgery, which is an increasingly safe procedure, also in infants. However, there are some complications to the surgery, which threatens ...