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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Exhaled nitric oxide in schoolchildren with asthma
(2004-11-19)
Background: The fraction of nitric oxide in exhaled air (FENO) is believed to reflect the degree of allergic inflammation present in the lower airways. The diffusing capacity of NO in the airways (DawNO) and the concentration ...
The role of adenosine and its receptor subtypes in nociception and neuropathic pain
(2005-05-27)
As neurotransmitter/modulator, adenosine plays an important role in nociceptive processing. Adenosine receptors are G-protein coupled and four receptor subtypes, A1, A2A, A2B and A3 have been identified. It is well established that adenosine and its...
Early oncogenic events and defective apoptosis in prostate cancer
(2005-03-18)
of genes involved in cell cycle regulation, apoptosis, and other biological functions. In our study, prostate cancer DU145 cells were grown in the presence of the DNA methylation inhibitor 5-aza-2'-deoxycytidine (5'-aza), followed by treatment...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione ill the presence of caesium carbonate. Several analogues of dipodazine, together with a few barettin analogues have been prepared and tested for activity ill antifouling assays, results and relevance of which...
Epstein-Barr virus nuclear antigen 1, Oct and Groucho/TLE in control of promoter regulation
(2005-11-04)
The human herpes virus Epstein-Barr virus (EBV) is carried by
approximately 95% of the adult population. It can form a lifelong latent
infection in the B-cells by avoiding our immune system. A latent EBV
infection is ...
Regulation of carbohydrate metabolism in skeletal muscle during and after contraction
(2006-11-03)
during exercise will lead to new strategies for treating or preventing increasingly prevalent diseases like type 2 diabetes. The aim of this thesis was to study the regulation of carbohydrate metabolism in skeletal muscle during and after contraction...
Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations
(2006-04-07)
This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as vasopressin that act through...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...