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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Tumor lipid status and the responses to therapy in neuroblastoma : with emphasis on treatment monitoring by proton magnetic resonance spectroscopy
(2004-11-18)
response of neuroblastoma xenografts
to the angiogenesis inhibitor TNP-470 was associated with an enhanced
lipid/choline ratio.
Neuroblastoma growth arrest induced by serum starvation in vitro was
associated with a decreased intensity of most 1H...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
(2006-02-24)
The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. A primary focus of this thesis...
T cells and costimulatory factors in myasthenia gravis
(2005-09-09)
The autoimmune disease myasthenia gravis (MG) is characterized by muscle weakness due to a loss of acetylcholine receptors (AChR) at the neuromuscular end plate. Most MG patients have pathogenic antibodies directed against ...
Physical activity in rheumatoid arthritis
(2006-04-28)
-six percent were able to complete a submaximal test of aerobic fitness. The main reasons for never being tested (16%) or for terminating testing prematurely (8%) were use of beta blockers or impairments. Correlations between work heart rates and perceived...
Cognitive functions in depression and anxiety disorders : findings from a population-based study
(2006-11-10)
This doctorial thesis examines cognitive functions in depression and anxiety disorders in a populationbased sample that includes mostly untreated persons. It is well established that depression is associated with cognitive ...
On neck load among helicopter pilots : effects of head worn equipment, whole body vibration and neck position
(2005-09-13)
at the highest vibration level at frequencies around 4-5 Hz. The induced load was also affected by both neck flexion and NVG. The load at 20° flexion increased by about 8 % of maximum voluntary contraction (MVC) compared to neutral and by about 3 % MVC when...
Molecular characterization of the Ro52 autoantigen and its disease related epitopes
(2005-01-14)
The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. ...
Renal cell death in urinary tract infections : role of E. coli toxins
(2005-01-28)
Febrile urinary tract infections (UTI) are common bacterial illnesses in children. Several follow up studies have shown that 10-15 % of infants with pyelonephritis will develop permanent renal damage, i.e., renal scars, ...