Search
Now showing items 1-10 of 179
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Application of nuclear medicine methods in patients with breast cancer
(2005-04-29)
While physical examination, mammography and aspiration cytology or core biopsy form the basis in the diagnosis of breast cancer, additional examinations are sometimes required in the evaluation of unclear breast masses. ...
Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
(2005-01-07)
Alzheimer’s disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component ...
The effects of some peptide hormones on osteoblast-like cells : with specific focus on oxytocin and vasopressin
(2005-01-07)
The nonapeptides oxytocin (OXT) and vasopressin (AVP) are mainly produced in the hypothalamus and released into the circulation through the neurohypophysis. Recently, an OXT-receptor was demonstrated in human osteoblast-like ...
Inflammation and matrix degrading proteases in coronary artery disease
(2006-05-26)
showed a protective effect against MI whereas the G-519-C-340 haplotype was associated with an increased risk of MI. Functional studies of gene expression demonstrated a lower promoter activity of the A-519 -C340 and G-519 -T-340 haplotypes than of the A...
The study of sensory cilia development in Caenorhabditis elegans
(2008-01-04)
Cilia and flagella are widespread eukaryotic subcellular components
that are conserved from green algae to mammals. In different organisms
they function in cell motility, movement of extracellular fluids and
sensory ...
Structure determination, thermal stability and catalytic mechanism of hyperthermostable isocitrate dehydrogenases
(2006-05-02)
In this thesis, studies on the enzyme isocitrate dehydrogenase (IDH) from the hyperthermophiles Aeropyrum pernix (ApIDH), Thermotoga maritima (TmIDH), Archaeoglobus fulgidus (AfIDH) and Pyrococcus furiosus (PfIDH) are ...
The analgesic mechanisms of buprenorphine
(2006-01-13)
Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic ...
Physical activity, body composition and physical self esteem among children and adolescents
(2005-02-25)
The increasing prevalence of overweight and obesity poses a global health problem. Special concern is focused on overweight during youth since it may cause negative impact on health both during childhood, adolescence and ...
Safety limit estimation for cataract induced by ultraviolet radiation
(2005-08-12)
Background: Ultraviolet radiation (UVR) is considered one of the major risk factors for agerelated cataract. UVR-induced cataract follows a continuous dose-response function. The concepts maximum acceptable dose (MAD) and ...