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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Physical activity, body composition and physical self esteem among children and adolescents
(2005-02-25)
The increasing prevalence of overweight and obesity poses a global health problem. Special concern is focused on overweight during youth since it may cause negative impact on health both during childhood, adolescence and ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
B. subtilis, A. aeolicus and a designed mutant LS from A. aeolicus (structure determined by cryo-EM in manuscript IV) were studied using small angle x-ray scattering (SAXS) and cryo-EM. The results indicate that multiple assembly states are a general...
Hidden Markov models for remote protein homology detection
(2005-12-23)
Genome sequencing projects are advancing at a staggering pace and are daily producing large amounts of sequence data. However, the experimental characterization of the encoded genes and proteins is lagging far behind. ...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
Maximal systolic and diastolic velocities recorded from four sites of the mitral annulus motion (MAM) reflect left ventricular (LV) performance. This thesis focus on factors influencing M-mode derived velocities in healthy ...
Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
Structure determination, thermal stability and catalytic mechanism of hyperthermostable isocitrate dehydrogenases
(2006-05-02)
In this thesis, studies on the enzyme isocitrate dehydrogenase (IDH) from the hyperthermophiles Aeropyrum pernix (ApIDH), Thermotoga maritima (TmIDH), Archaeoglobus fulgidus (AfIDH) and Pyrococcus furiosus (PfIDH) are ...
Prevention of complications in pediatric cataract surgery
(2004-11-26)
This thesis was performed to find ways to lessen the complications to pediatric cataract surgery, which is an increasingly safe procedure, also in infants. However, there are some complications to the surgery, which threatens ...
Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts
(2005-11-11)
Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes collectively responsible for the metabolism of extra cellular matrix components. Disturbance of the physiological balance between MMPs and their endogenous ...
Environmental influence on alpha-helical peptides
(2006-11-16)
Most proteins at physiological conditions fold into a native functional three-dimensional conformation. The stability of the Native state is a balance between different interactions within the protein and with the solvent. ...