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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by ...
Five-year follow-up of a randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke
(2005-11-23)
rehabilitation in southwest Stockholm.
Methods: Eighty-three patients with mild to moderate disability 5 to 7 days after acute stroke, were enrolled in the RCT from September 1993 to April 1996. Patients who had participated in the 12months follow-up and who...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis in vivo. The following...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
-RVm) were used for recordings of RVm and according to Fisher's exact test both methods can be used to detect diastolic dysfunction but velocities obtained by TD-RVm was 29.7% (p<0.0001) higher than M-RVm. Sensitivity and specificity for M-RVm to correctly...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
Viridans group streptococci (VGS) are inhabitants in the oral cavity and in the gastrointestinal tract. They cause severe infections, they are responsible for up to 39 % of the cases of septicaemia in neutropenic patients ...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Patellar tendinopathy : on evaluation methods and rehabilitation techniques
(2006-10-27)
Background: Patellar tendinopathy is an increasingly common overuse and degenerative injury for recreational and elite athletes. The management of this injury is often difficult and frustrating and the treatment may take ...
Incidence and prognosis of differentiated thyroid cancer in Sweden
(2006-01-06)
with distant metastasis a 7-fold higher risk of death compared with those with no metastases. Non-surgically treated patients had a worsened prognosis. Incomplete surgical excision was associated with higher mortality, particularly among patients in stage I...