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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Cyanoacetylation of indoles, pyrroles and amines, and synthetic uses of these products
(2005-02-25)
This thesis is based on an organic synthetic project aimed towards development of small molecules acting on the P2 receptor as well as development of synthetic methods to such molecules (primarily indoles and featuring ...
Molecular basis of estrogen receptor antagonism
(2006-01-27)
after binding of uncharacterized ligands.
Phytoestrogens, such as genistein, are being extensively investigated in search of new therapeutic agents for estroge n-related pathologies. 8-prenylnaringenin is a potent plantderived estrogenic compound...
Genome instability, gene expression and prognosis in breast cancer
(2005-02-18)
carcinoma that proved to be genomically stable.
In image cytometric DNA histograms this subtype possessed a low percentage (<8.8%) of nonmodal DNA values as measured by the stemline scatter index (SSI), which is defined as sum of the percentage of cells...
Synthesis of indoles, bisindoles and indolocarbazoles : high affinity aryl hydrocarbon receptor ligands
(2004-09-03)
prepared in a Lewis acid mediated acylation involving different
indoles and indolyl-2-carbonyl chlorides. Synthesis of the metabolites
proved the assigned structures as 2-hydroxy-, 8-hydroxy-,
2,10-dihydroxy-, 4,8-dihydroxy- and 2,8dihydroxyindolo[3,2-b...
Glutathione during stress in man
(2006-05-12)
[7]. Muscle glutathione depletion has been shown to correlate with mortality in septic ICU patients [8]. The consequences of glutathione depletion seen in septic patients are not fully understood. In this thesis work new insights into the glutathione...
Design and synthesis of steroid mimetic libraries using solid phase techniques
(2004-09-10)
This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques.
In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure...
Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis
(2004-08-20)
, and
thus it is important to understand the interaction and communication
between these different cell types.
The role of CD8+ T cells in perpetuating EAE was studied using
genetically modified mice, and CD8+ T cells were determined to have an
integral...
Nitric oxide : a surrogate marker of bowel inflammation
(2005-10-28)
% and specificity of 91 % in discriminating between IBS and active IBD. Rectal levels of NO were correlated to disease activity in patients with IBD or CC and were reduced markedly in IBD patients who responded to treatment. Surprisingly, rectal levels of NO were...
Ancestral influences on health of grandchildren
(2005-03-22)
The late effects in adulthood of nutrition during adolescence, childhood, infancy, and the fetal and embryonic stages of development have attracted much attention in research, but less so the time of development of the ...