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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Functional studies of the multiple endocrine neoplasia type 1 gene
(2004-10-22)
The multiple endocrine neoplasia type 1 (MEN1, OMIM 131 100) syndrome is
an autosomal dominant trait with a near 100% penetrance and with an
estimated prevalence of 2-20/100 000. The syndrome is characterized by
neoplasia ...
Diet and ovarian cancer : a population-based cohort of 60 000 women
(2005-05-06)
.0 (95% CI, 1.2-3.4; P trend = 0.01) for the highest versus
the lowest quartile of lactose intake. High consumption of milk, the main
source of lactose, was also associated with a greater risk of serous
ovarian cancer. The multivariate RR for women who...
Influence of maternal allergy on the intra uterine environment and on immune functions of the neonate
(2005-02-25)
) on villous trophoblast, whereas no immune reactivity was present in the villous core. The intermediate trophoblast was also found to express both TLR2 and TLR4. Regulation of TLR2 and TLR4 was investigated by stimulating placental explants with LPS...
Structural and functional studies of microsomal glutathione transferase 1
(2005-05-13)
Proteins in Eicosanoid and Glutathione Metabolism ~PEG) together with the two other microsomal glutathione transferases 2 and 3, microsomal prostaglandin E synthase 1 (MPGES1), leukotriene C4 synthase and 5-lipoxygenase activating protein.
This thesis...
On gallstone disease : complications and surgical treatment
(2005-11-18)
, with or without CBDS in 24.4%. In the long-term study of LCBDE, 90% of the questionnaires were returned at a mean follow-up of 36 months. Six re-interventions had been performed, but no suspicion of bile duct stricture or mortality related to the prior surgery...
Exercise and angiogenic growth factors in human skeletal muscle
(2005-05-20)
Long-term electrical stimulation and endurance exercise increase the amount of capillaries in skeletal muscle. VEGF-A is a well-characterized stimulatory angiogenic growth factor and has shown to play an important role in ...
Targeting insulin-like growth factor-1 receptor in cancer
(2004-09-24)
Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
)] and 841 woman [mean age = 35.7 years (±2.9 SD)] who participated in an epidemiological study of periodontal health that was started in 1985, 2.4 % were found to exhibit foetor ex ore and 1 % were diagnosed as having halitophobia. Subjects with both...