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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
-PSOX, which mediates uptake of oxidized low-density lipoprotein (oxLDL) by cells. We detected abundant CXCL16/SR-PSOX and CXCR6 expression in atherosclerotic lesions from human subjects and apolipoprotein-Edeficient (ApoE-/-) mice. In monocytes, CXCL16/SR...
Effect of estrogen on longitudinal bone growth
(2006-04-14)
Longitudinal bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and the metaphysis of long bones. In the growth plate resting chondrocytes proliferate, differentiate into a hypertrophic ...
Regulation of gene and protein expression : two model systems
(2005-11-25)
CycT1) and mouse CycT 1 (mCycT1), eCycT1 contains critical amino acid residues for function for both HIV-1 (C261) and EIAV (C261 and H79-80R). We show that panCycT1 and hCycT1 are conserved at C261. We show that hCycT1 increases HIV-1 p24 production from...
Health-related quality of life, treatment satisfaction and clinical aspects of patients with primary antibody deficiency receiving subcutaneous IgG self-infusions at home
(2006-10-20)
Patients with primary antibody deficiencies (PAD) are unable to produce sufficient amounts of antibodies and are therefore susceptible to severe bacterial infections. The standard therapy has been intravenous infusions of ...
Basic and translational studies of follicular thyroid neoplasia
(2005-04-08)
Thyroid tumors occur frequently in the general population and although the majority represents benign follicular adenomas (FTA), thyroid cancer constitutes 1% of all malignancies worldwide. Among the differentiated cancers, ...
Studies on fat cell function in human obesity and insulin resistance
(2005-09-30)
Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks ...
Develop your memory strategies! Self-generated versus mnemonic strategy training in old age : maintenance, forgetting, transfer and age differences
(2005-04-08)
The general aim of this thesis was to further our understanding of
episodic memory plasticity in normal aging, by examining the
effectiveness of a mnemonic-strategy training program versus a
self-generated memory strategy ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
Bad breath usually originates within the oral cavity and is believed to be associated with periodontal disease. The over all aim of the present thesis was to study periodontal conditions in subjects with bad breath as well ...