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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Resistance to antiviral drugs in HIV and HBV
(2005-02-18)
Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for ...
Pharmacodynamic interactions of quinolines with other antimalarial compounds in vitro
(2005-05-03)
Chemotherapy remains the most reliable means for the control of Plasmodium falciparum malaria. Unfortunately the parasite has been able to develop resistance to the majority of the antimalarials currently employed.
Success ...
Immunological and virologica response to antiretroviral treatment (art) in patients infected with different HIV-1 genetic subtypes
(2006-02-17)
similarly.
Paper II: Other parameters of immune activation that we have evaluated are IL-7 and its receptor. The expression of the EL-7Ralpha, in T cells from HIV-1 patients was studied in relation to CD4+T cell counts, IL-7 concentration, T cell...
Nutritional status and cognitive function in frail elderly subjects
(2004-08-13)
Longevity, frailty and chronic disease are often associated with protein energy-malnutrition (PEM). Subjects with dementia are at particular risk for PEM. The overall aims of this thesis were to evaluate relationships ...
Search for susceptibility loci and candidate genes for breast cancer
(2004-11-26)
and 17p13 were the two main candidate regions in the twins. 16q22.1, 17q21 and 13q14 may also be involved in a subset of the twins. Chromosome 1 did not seem to carry any important tumor suppressor gene in our sample set.
· Estradiol is one...
The epidemiology of low back pain in the general population and after motor vehicle collisions : population-based investigations
(2004-11-23)
prevalence of LBP in Saskatchewan adults was 28.4%
and 84. 1 % respectively. The six-month prevalence of mild, intense and
disabling LBP was 48.8%, 12.3 % and 10.7% respectively. There was little
variation in prevalence across age groups, but women...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...