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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
wild type (allele*l) and 3 different mutations of enzyme (alleles *4 and *6, and mutation G516T) was investigated. All three mutations have less activity for the hydroxylation of CPA compared to CYP2116* 1 (wild type).
Ciprofloxacin altered CPA...
Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells
(2004-09-01)
[d]anthracene-3,4dicarboxylic acid (ABADA) exhibits any toxicological activity in cultured colonic cells. ABADA was shown to have weak mutagenic activity in Salmonella typhimurium strain TA 102 (detects oxidative mutagens). The cytotoxicity of ABADA seen in HCT...
Opioid ligands and receptors of the joint
(2006-04-28)
, this approach seems preferable for quantification of opioids ligands in joints.
To explore the target for enkephalins and opiates, in vitro opioid receptor (OR) binding assays were done on preparations from rat capsule/synovium and periosteum. Binding of [3H...
Penicillin-resistant pneumococci in Sweden : epidemiology and public health response
(2005-12-30)
, as the observed duration of carriage became significantly shorter for each increasing age-step <1 years, 1-2 years and 3-4 years. In addition, cases aged < 5 years carried serogroup 9 and 14 for significantly shorter periods compared with group 6 and 23. Serogroup...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
factors. In scrum most IGF circulate in a ternary complex with IGF-binding protein-3 (IGFBP-3) and the acid labile subunit (ALS). The affinity between IGF and IGFBP-3 exceeds that between IGF and the type 1 IGF receptor demonstrating that most...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Patient-orientated aspects of the postoperative course after hernia surgery
(2006-09-01)
on the discordance between the patient's and the surgeon's perception of complications. Some 206 patients having surgery for inguinal hernia were invited to a follow-up 3-6 weeks after the operation. The patient was asked to fill in a questionnaire with 12 questions...
A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation
(2006-08-25)
Immediately upon transcription, messenger RNA molecules become associated with proteins to form ribonucleoprotein (RNP) complexes, usually called mRNP particles. The mRNPs are the actual targets for regulation and dictate ...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha ...