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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Adaptive responses during giardia-host interactions
(2005-01-28)
Giardia lamblia is a major cause of water-borne enteric disease. The parasite is a noninvasive, flagellated protozoan that inhabits the upper part of the small intestine of its vertebrate hosts. Differentiation is central ...
Immunodominant proteins in Giardia lamblia
(2004-11-19)
The protozoan parasite Giardia lamblia is a major cause of diarrhoea in
humans and other mammals. Infection starts by ingestion of infectious
cysts that excyst in the upper part of the small intestine and attach ...
Nutritional status and cognitive function in frail elderly subjects
(2004-08-13)
weight gain of 3.4 ±11.2 kg (p=0.00 1) 6 months later, that was not seen in the control group. The weight gain was not related to an improvement in ADL capacity or cognitive function (MMSE). A BMI <23 was noticed in more than half of 231 patients admitted...
Brain cholesterol metabolism : a study of mouse and man
(2005-09-16)
. Preliminary findings also indicated that
7alphahydroxy3-oxo-4-cholestenoic acid may be fluxing out of the brain, a
steroid which can be formed in the brain from 27hydroxycholesterol.
Cholesterol 24-hydroxylase or CYP46A1, oxidises cholesterol to
24S...
Application of nuclear medicine methods in patients with breast cancer
(2005-04-29)
While physical examination, mammography and aspiration cytology or core biopsy form the basis in the diagnosis of breast cancer, additional examinations are sometimes required in the evaluation of unclear breast masses. ...
Bacterial virulence and adaptation mediated by two-component system signalling
(2006-05-25)
A-UvrY TCS signaling. The yhdA gene encodes a 646 amino acid protein containing both a GGDEF-like and an EAL-like domain. These domains are involved in formation and breakdown of 3',5'-cyclic diguanylic acid (c-di-GMP), a second messenger important...
Selective induction of apoptosis in tumors by small molecules reactivating p53
(2005-01-21)
with no apparent toxicity.
We also showed that rationally designed nine-residue peptide CDB3 that bound to the tumor suppressor p53 and stabilized it against denaturation in vitro, binds p53 in cells, restores the active conformation and transcription...
Regulation of gene and protein expression : two model systems
(2005-11-25)
Genetic information is expressed by DNA transcription and mRNA translation. With few exceptions, every cell of an organism, or the human body, contains the same genetic information. Yet the structure and function of different ...
Clinical and experimental studies on HFE and other genes involved in iron homeostasis
(2004-09-17)
In this thesis, the clinical significance of HFE mutations was further investigated, and the molecular mechanisms underlying the disturbed iron homeostasis during hemochromatosis, inflammation and hepatocellular carcinoma ...