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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Resistance to antiviral drugs in HIV and HBV
(2005-02-18)
of infection with resistant HIV-1 variants among patients diagnosed at Venhälsan, Södersjukhuset during the last 10 years. From a total of 185 newly diagnosed patients, 24 with resistance-associated mutations were found. The patients with mutations have also...
A prospective study of mental health among mass-evacuated Kosovo Albanians
(2006-02-17)
Mental health outcomes among traumatised refugees have been of interest to researchers for decades. However, so far little is known about specific refugee groups such as asylum seekers and temporary mass-evacuees although ...
Maternal morbidity in Uganda : studies on life-threatening pregnancy complications in low-income settings
(2004-11-25)
relations, HIV/AIDS, pregnancy and abortion. Content
analysis was used to describe the findings (Paper 5).
Results: HIV infection was not found to correlate with the risk for PAEM,
HIV-1 seroprevalence 17 (32.7%) among women with PAEM and 38 (36.5%)
among...
Bacterial virulence and adaptation mediated by two-component system signalling
(2006-05-25)
One of the most fundamental ways of signal perception and propagation is mediated by the bacterial two-component system (TCS). These types of systems mediate bacterial adaptation that may cause disease in a host due to ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
)] and 841 woman [mean age = 35.7 years (±2.9 SD)] who participated in an epidemiological study of periodontal health that was started in 1985, 2.4 % were found to exhibit foetor ex ore and 1 % were diagnosed as having halitophobia. Subjects with both...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children ...