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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Rotavirus in pediatric gastroenteritis in Nicaraguan children
(2004-10-26)
cost of more than USD 270,000 from the Health
care sources. If all cases of severe diarrhea are considered, including
other etiologies of gastroenteritis, the total cost burden amounts to
more than USD 800,000, a sum that represents around 0...
Mild head injury : inhospital observation or computed tomography?
(2005-11-25)
Background: Patients with mild head injuries are treated every day in emergency
departments around the world. The rationale for any management strategy
is to identify with a high degree of safety at reasonable costs, ...
Molecular studies of Neisseria : host cell interactions
(2004-08-11)
The Neisseria family includes many non-pathogenic species but also two strict human pathogens; Neisseria gonorrhoeae and Neisseria meningitidis. Both organisms colonise mucosal surfaces and may cause disseminated infections ...
The natural history of HIV-1 infection and preparations for HIV vaccine trials in Tanzania
(2006-09-08)
useful information for HIV intervention strategies, including vaccine development.
Prevalence of sexually transmitted infections (STI's) at baseline among the workers was 16.6% (236/1422) and 15.5% (72/465) in males and females respectively, p=0...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment
(2005-11-25)
, rats, mice and hamsters, whereas increased renal vitamin
A levels were observed only in the rat. Hepatic vitamin A gain was
decreased 25% compared to control at estimated doses of 0.1, 1.1, 3.6 and
0.9 µg/kg bw respectively for guinea pigs, rats, mice...
Xenobiotics-induced phosphorylations of MDM2
(2006-11-24)
, and have also anticarcinogenic properties. The attenuation of p53 DNA damage response was associated with Mdm2 phosphorylation on Ser166. Thus, statins and TCDD induces Mdm2 Ser166. phosphorylation and attenuates p53 stabilization in response to DNA damage...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
disease was 5.1-fold and 3.8-fold increased in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was about 8-fold elevated in water pipe smokers and 5-fold elevated...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Dietary and genetic factors in the etiology of prostate cancer
(2006-05-19)
The etiology of prostate cancer is poorly understood. However, genetic factors may be more important than for many other malignancies. In addition, several studies suggest that dietary factors axe of etiologic importance. ...