Search
Now showing items 1-10 of 33
Post-traumatic stress disorder and life events among recently resettled refuges
(2002-09-27)
clinical assessment for posttraumatic stress disorder. Questionnaires were translated into Arabic and South Kurdic and back-translated.
Results: The prevalence of PTSD among the participants was 37,2 % and was higher among males than females, consistent...
Molecular genetics of type 2 diabetes
(2002-04-24)
Type 2 diabetes is a common and chronic disease caused by interactions between genetic and environmental factors. The Goto-Kakizaki (GK) rat is a well-established genetic model of type 2 diabetes. Since several aspects of the pathophysiology...
Immunogenetic studies in autoimmune endocrine diseases
(2003-11-25)
autoimmune process. The strongest genetic association identified is that with HLA class II genes located on the short arm of chromosome 6. It is well known that both HLA DRB1*04-DQA1*0301DQB1*0302 (DR4-DQ8) and DRB1*03DQA1*0501-DQB1*0201 (DR3-DQ2...
Studies of cell migration and matrix protease production in human lung cancer cell lines
(2004-09-03)
III, we used gelatine zymography to
demonstrate that three NSCLC cell lines express matrix metalloproteases
(MMPs) -9 and -2. The expression and activity of MMP-9 and MMP-2 was
heterogeneous in these cell lines. In addition, we showed that growth...
Vector development for suicide gene therapy
(2002-05-03)
-mediated integration in several cultured cell lines as well as
primary human donor T-lymphocytes (Paper IV).
We have prepared suicide gene therapy vectors containing HSV-tk and OuaR
selection marker fusion gene in extensively optimised retroviral backbone
SF91...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. Aa is produced...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
IDDM is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting B- cells. GAD65 and IA-2 are major B-cell specific autoantibodies and are not found in healthy population. IDDM is associated with certain HLA class II...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
induction therapy, in combination with ribavirin during treatment of naive patients, also resulted in a small but significantly more pronounced HCV RNA decline compared to standard dosing, in genotype non-1 infected patients but only day 2 and 7 during...
HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden
(2001-08-08)
Infection with human papillomaviruses (HPV) types 16 and 18 is the major
cause of cervical neoplasia. Although a high proportion of cervical
cancers (CXCA) harbor HPV genomes, only a small number of women infected
with ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
in most malignant human tumors. Most intriguingly, both p53 and Rb proteins are in part regulated through the CDKN2A (INK4a/ARF) locus on human chromosome 9p21, a region frequently lost in tumors. This region encodes two structurally and functionally...